Ontology highlight
ABSTRACT:
SUBMITTER: Babour A
PROVIDER: S-EPMC3359143 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Cell 20100708 2
The endoplasmic reticulum (ER) plays an essential role in the production of lipids and secretory proteins. Because the ER cannot be generated de novo, it must be faithfully transmitted or divided at each cell division. Little is known of how cells monitor the functionality of the ER during the cell cycle or how this regulates inheritance. We report here that ER stress in S. cerevisiae activates the MAP kinase Slt2 in a new ER stress surveillance (ERSU) pathway, independent of the unfolded protei ...[more]