Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria.
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ABSTRACT:
SUBMITTER: Lau E
PROVIDER: S-EPMC3359149 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria.
Lau Edward E Wang Ding D Zhang Jun J Yu Hongxiu H Lam Maggie P Y MP Liang Xiangbo X Zong Nobel N Kim Tae-Young TY Ping Peipei P
Circulation research 20120327 9
<h4>Rationale</h4>Mitochondrial protein homeostasis is an essential component of the functions and oxidative stress responses of the heart.<h4>Objective</h4>To determine the specificity and efficiency of proteome turnover of the cardiac mitochondria by endogenous and exogenous proteolytic mechanisms.<h4>Methods and results</h4>Proteolytic degradation of the murine cardiac mitochondria was assessed by 2-dimensional differential gel electrophoresis and liquid chromatography-tandem mass spectrometr ...[more]
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