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Design, synthesis, and diversification of 3,5-substituted enone library.

ABSTRACT: This paper describes the synthesis of a 300 member library of 3,5-substituted enones. The synthesis starts with 6 different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a variety of aromatic and vinyl boronic acids. Additionally a small series of triazoles was synthesized by a Sonogashira coupling reaction dipolar cycloaddition sequence. The library was analyzed by principal component analysis to examine its diversity.

SUBMITTER: Khalaf J

PROVIDER: S-EPMC3360050 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Design, synthesis, and diversification of 3,5-substituted enone library.

Khalaf Juhienah J Estrella-Jimenez Maria E ME Shashack Matthew J MJ Phatak Sharangdhar S SS Zhang Shuxing S Gilbertson Scott R SR

ACS combinatorial science 20110622 4

This paper describes the synthesis of a 300 member library of 3,5-substituted enones. The synthesis starts with 6 different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a variety of aromatic and vinyl boronic acids. Additionally a small series of triazoles was synthesized by a Sonogashira coupling reaction dipolar cycloaddition sequence. The library was analyzed by principal component analysis to examine its diversit ...[more]

PMID: 21648460

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