Ontology highlight
ABSTRACT:
SUBMITTER: Rosu S
PROVIDER: S-EPMC3360972 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Rosu Simona S Libuda Diana E DE Villeneuve Anne M AM
Science (New York, N.Y.) 20111201 6060
Most organisms rely on interhomolog crossovers (COs) to ensure proper meiotic chromosome segregation but make few COs per chromosome pair. By monitoring repair events at a defined double-strand break (DSB) site during Caenorhabditis elegans meiosis, we reveal mechanisms that ensure formation of the obligate CO while limiting CO number. We find that CO is the preferred DSB repair outcome in the absence of inhibitory effects of other (nascent) recombination events. Thus, a single DSB per chromosom ...[more]