A framework for mapping, visualisation and automatic model creation of signal-transduction networks.
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ABSTRACT:
SUBMITTER: Tiger CF
PROVIDER: S-EPMC3361003 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
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A framework for mapping, visualisation and automatic model creation of signal-transduction networks.
Tiger Carl-Fredrik CF Krause Falko F Cedersund Gunnar G Palmér Robert R Klipp Edda E Hohmann Stefan S Kitano Hiroaki H Krantz Marcus M
Molecular systems biology 20120424
Intracellular signalling systems are highly complex. This complexity makes handling, analysis and visualisation of available knowledge a major challenge in current signalling research. Here, we present a novel framework for mapping signal-transduction networks that avoids the combinatorial explosion by breaking down the network in reaction and contingency information. It provides two new visualisation methods and automatic export to mathematical models. We use this framework to compile the prese ...[more]
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