CD8+ T cells: GITR matters.
Ontology highlight
ABSTRACT:
SUBMITTER: Ronchetti S
PROVIDER: S-EPMC3361162 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
CD8+ T cells: GITR matters.
Ronchetti Simona S Nocentini Giuseppe G Petrillo Maria Grazia MG Riccardi Carlo C
TheScientificWorldJournal 20120430
As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8(+) T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR function in CD8(+) cells, paying particular attention to numerous and recent studies that suggest its cru ...[more]
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