Ontology highlight
ABSTRACT:
SUBMITTER: Cole C
PROVIDER: S-EPMC3361567 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cole Caroline C Thomas Stacey S Filak Holly H Henson Peter M PM Lenz Laurel L LL
Immunity 20120426 5
Toll-like receptor (TLR) stimulation activates macrophages to resist intracellular pathogens. Yet, the intracellular bacterium Listeria monocytogenes (Lm) causes lethal infections in spite of innate immune cell activation. Lm uses direct cell-cell spread to disseminate within its host. Here, we have shown that TLR-activated macrophages killed cell-free Lm but failed to prevent infection by spreading Lm. Instead, TLR signals increased the efficiency of Lm spread from "donor" to "recipient" macrop ...[more]