Inflammation modulates human HDL composition and function in vivo.
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ABSTRACT:
SUBMITTER: de la Llera Moya M
PROVIDER: S-EPMC3361641 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Inflammation modulates human HDL composition and function in vivo.
de la Llera Moya Margarita M McGillicuddy Fiona C FC Hinkle Christine C CC Byrne Michael M Joshi Michelle R MR Nguyen Vihn V Tabita-Martinez Jennifer J Wolfe Megan L ML Badellino Karen K Pruscino Leticia L Mehta Nehal N NN Asztalos Bela F BF Reilly Muredach P MP
Atherosclerosis 20120228 2
<h4>Objectives</h4>Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans.<h4>Methods and results</h4>We employed low-dose human endotoxemia to assess the effects of inflammation on HDL and RCT-related parameters in vivo. Endotoxemia induced remodelling of HDL with depletion of pre-β1a HDL particles determined by 2-D gel electrophoresis (-32.2±9.3% at 24 h, p<0.05) as well as small (-23.0±5.1%, p<0.01, at ...[more]
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