Ontology highlight
ABSTRACT:
SUBMITTER: Cuesta AM
PROVIDER: S-EPMC3361658 | biostudies-literature | 2012 Mar-Apr
REPOSITORIES: biostudies-literature
Cuesta Angel M AM Sánchez-Martín David D Blanco-Toribio Ana A Villate Maider M Enciso-Álvarez Kelly K Alvarez-Cienfuegos Ana A Sainz-Pastor Noelia N Sanz Laura L Blanco Francisco J FJ Alvarez-Vallina Luis L
mAbs 20120301 2
We recently described the in vitro and in vivo properties of an engineered homotrimeric antibody made by fusing the N-terminal trimerization region of collagen XVIII NC1 domain to the C-terminus of a scFv fragment [trimerbody (scFv-NC1) 3; 110 kDa]. Here, we demonstrated the utility of the N-terminal trimerization region of collagen XV NC1 domain in the engineering of trivalent antibodies. We constructed several scFv-based trimerbodies containing the human type XV trimerization domain and demons ...[more]