Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease.
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SUBMITTER: Min HK
PROVIDER: S-EPMC3361911 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
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Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease.
Min Hae-Ki HK Kapoor Ashwani A Fuchs Michael M Mirshahi Faridoddin F Zhou Huiping H Maher James J Kellum John J Warnick Russell R Contos Melissa J MJ Sanyal Arun J AJ
Cell metabolism 20120501 5
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride and free cholesterol (FC) accumulation without a corresponding increment in cholesterol esters. The aim of this study was to evaluate the expression of cholesterol metabolic genes in NAFLD and relate these to disease phenotype. NAFLD was associated with increased SREBP-2 maturation, HMG CoA reductase (HMGCR) expression and decreased phospho ...[more]
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