Ontology highlight
ABSTRACT:
SUBMITTER: McElroy JP
PROVIDER: S-EPMC3361962 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
McElroy J P JP Isobe N N Gourraud P A PA Caillier S J SJ Matsushita T T Kohriyama T T Miyamoto K K Nakatsuji Y Y Miki T T Hauser S L SL Oksenberg J R JR Kira J J
Genes and immunity 20110609 7
Although several major histocompatibility complex (MHC)-wide single-nucleotide polymorphism (SNP) studies have been performed in populations of European descent, none have been performed in Asian populations. The objective of this study was to identify human leukocyte antigen (HLA) loci associated with multiple sclerosis (MS) in a Japanese population genotyped for 3534 MHC region SNPs. Using a logistic regression model, two SNPs (MHC Class III SNP rs422951 in the NOTCH4 gene and MHC Class II SNP ...[more]