Unique sex-based approach identifies transcriptomic biomarkers associated with non-syndromic craniosynostosis.

ABSTRACT:

Background

The premature fusion of one cranial suture, also referred to as non-syndromic craniosynostosis, most commonly involves premature fusion of the sagittal, coronal, or metopic sutures, in that order. Population-based epidemiological studies have found that the birth prevalence of single-suture craniosynostosis is both suture- and sex-dependent.

Methods

Transcriptomic data from 199 individuals with isolated sagittal (n = 100), unilateral coronal (n = 50), and metopic (n = 49) synostosis were compared against a control population (n = 50) to identify transcripts accounting for the different sex-based frequencies observed in this disease.

Results

Differential sex-based gene expression was classified as either gained (divergent) or lost (convergent) in affected in

SUBMITTER: Stamper BD 

PROVIDER: S-EPMC3362332 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature