Ontology highlight
ABSTRACT:
SUBMITTER: Thliveris AT
PROVIDER: S-EPMC3362940 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Thliveris Andrew T AT Clipson Linda L Sommer Lacy L LL Schoenike Barry A BA Hasenstein Jason R JR Schlamp Cassandra L CL Alexander Caroline M CM Newton Michael A MA Dove William F WF Amos-Landgraf James M JM
G3 (Bethesda, Md.) 20120501 5
The gene-trap lacZ reporter insertion, ROSA11, in the Cbx5 mouse gene illuminates the regulatory complexity of this locus in Apc(Min) (/+) mice. The insertion site of the β-Geo gene-trap element lies in the 24-kb intron proximal to the coding region of Cbx5. Transcript analysis indicates that two promoters for Cbx5 flank this insertion site. Heterozygotes for the insertion express lacZ widely in fetal tissues but show limited expression in adult tissues. In the intestine, strong expression is li ...[more]