Ontology highlight
ABSTRACT:
SUBMITTER: Nandhikonda P
PROVIDER: S-EPMC3364162 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Nandhikonda Premchendar P Lynt Wen Z WZ McCallum Megan M MM Ara Tahniyath T Baranowski Athena M AM Yuan Nina Y NY Pearson Dana D Bikle Daniel D DD Guy R Kiplin RK Arnold Leggy A LA
Journal of medicinal chemistry 20120516 10
The vitamin D receptor (VDR) is a nuclear hormone receptor that regulates cell proliferation, cell differentiation, and calcium homeostasis. The receptor is activated by vitamin D analogues that induce the disruption of VDR-corepressor binding and promote VDR-coactivator interactions. The interactions between VDR and coregulators are essential for VDR-mediated transcription. Small molecule inhibition of VDR-coregulator binding represents an alternative method to the traditional ligand-based appr ...[more]