Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC3364922 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Wu Xin X Peppi Marcello M Vengalil Matthew J MJ Maheras Kathleen J KJ Southwood Cherie M CM Bradley Michael M Gow Alexander A
Biology of reproduction 20120503 5
Claudins comprise a large family of tight junction (TJ) proteins that are often expressed broadly during development and in adult tissues and constitute the physical barriers that occlude the paracellular space in polarized epithelia. In mouse testis, the integrity of TJs is critical to normal spermatogenesis and is dependent on CLDN11 expression. In the current study, we have generated multiple transgenic mouse lines in which steady-state levels of transgene-derived Cldn11 mRNA are up to fourfo ...[more]