Ontology highlight
ABSTRACT:
SUBMITTER: Jeon SG
PROVIDER: S-EPMC3364948 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Jeon Seong Gyu SG Kayama Hisako H Ueda Yoshiyasu Y Takahashi Takuya T Asahara Takashi T Tsuji Hirokazu H Tsuji Noriko M NM Kiyono Hiroshi H Ma Ji Su JS Kusu Takashi T Okumura Ryu R Hara Hiromitsu H Yoshida Hiroki H Yamamoto Masahiro M Nomoto Koji K Takeda Kiyoshi K
PLoS pathogens 20120531 5
Specific intestinal microbiota has been shown to induce Foxp3(+) regulatory T cell development. However, it remains unclear how development of another regulatory T cell subset, Tr1 cells, is regulated in the intestine. Here, we analyzed the role of two probiotic strains of intestinal bacteria, Lactobacillus casei and Bifidobacterium breve in T cell development in the intestine. B. breve, but not L. casei, induced development of IL-10-producing Tr1 cells that express cMaf, IL-21, and Ahr in the l ...[more]