Conserved expression signatures between medaka and human pigment cell tumors.
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ABSTRACT:
SUBMITTER: Schartl M
PROVIDER: S-EPMC3365055 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Conserved expression signatures between medaka and human pigment cell tumors.
Schartl Manfred M Kneitz Susanne S Wilde Brigitta B Wagner Toni T Henkel Christiaan V CV Spaink Herman P HP Meierjohann Svenja S
PloS one 20120531 5
Aberrations in gene expression are a hallmark of cancer cells. Differential tumor-specific transcript levels of single genes or whole sets of genes may be critical for the neoplastic phenotype and important for therapeutic considerations or useful as biomarkers. As an approach to filter out such relevant expression differences from the plethora of changes noted in global expression profiling studies, we searched for changes of gene expression levels that are conserved. Transcriptomes from massiv ...[more]
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