Ontology highlight
ABSTRACT:
SUBMITTER: Duffield GE
PROVIDER: S-EPMC3365105 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120531 5
Glutamate neurotransmission and the N-methyl-D-aspartate receptor (NMDAR) are central to photic signaling to the master circadian pacemaker located in the hypothalamic suprachiasmatic nucleus (SCN). NMDARs also play important roles in brain development including visual input circuits. The functional NMDAR is comprised of multiple subunits, but each requiring the NR1 subunit for normal activity. The NR1 can be alternatively spliced to produce isoforms that confer different functional properties o ...[more]