Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez-Romaguera J
PROVIDER: S-EPMC3365168 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Rodriguez-Romaguera Jose J Do Monte Fabricio H M FH Quirk Gregory J GJ
Proceedings of the National Academy of Sciences of the United States of America 20120514 22
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) reduces symptoms of intractable obsessive-compulsive disorder (OCD), but the mechanism of action is unknown. OCD is characterized by avoidance behaviors that fail to extinguish, and DBS could act, in part, by facilitating extinction of fear. We investigated this possibility by using auditory fear conditioning in rats, for which the circuits of fear extinction are well characterized. We found that DBS of the VS (the VC/V ...[more]