Ontology highlight
ABSTRACT:
SUBMITTER: Norris PC
PROVIDER: S-EPMC3365225 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20120514 22
Dietary fish oil containing ω3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), elicit cardioprotective and anti-inflammatory effects through unresolved mechanisms that may involve competition and inhibition at multiple levels. Here, we report the effects of arachidonic acid (AA), EPA, and DHA supplementation on membrane incorporation, phospholipase A(2) catalyzed release, and eicosanoid production in RAW264.7 macrophages. Using a targeted lipidomics approach, we observed ...[more]