Ontology highlight
ABSTRACT:
SUBMITTER: Rothenbusch U
PROVIDER: S-EPMC3365415 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Rothenbusch Ute U Sawatzki Marc M Chang Yiming Y Caesar Stefanie S Schlenstedt Gabriel G
The EMBO journal 20120504 11
The nuclear import receptor Kap114 carries transcription factors and other cargos across nuclear pores into the nucleus. Here we show that yeast Kap114 is modified by SUMO (small ubiquitin-related modifier) and that sumoylation is required for Kap114-mediated nuclear import. Among the four known SUMO-specific E3 ligases in yeast, Mms21 is the preferred E3 enzyme responsible for the covalent attachment of SUMO to the Kap114 protein. Kap114 is sumoylated on lysine residue 909, which is part of a Ψ ...[more]