Ontology highlight
ABSTRACT:
SUBMITTER: Luijsterburg MS
PROVIDER: S-EPMC3365417 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
The EMBO journal 20120424 11
The ubiquitin ligases RNF8 and RNF168 orchestrate DNA damage signalling through the ubiquitylation of histone H2A and the recruitment of downstream repair factors. Here, we demonstrate that RNF8, but not RNF168 or the canonical H2A ubiquitin ligase RNF2, mediates extensive chromatin decondensation. Our data show that CHD4, the catalytic subunit of the NuRD complex, interacts with RNF8 and is essential for RNF8-mediated chromatin unfolding. The chromatin remodelling activity of CHD4 promotes effi ...[more]