Neurod1 is essential for the survival and maturation of adult-born neurons.
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ABSTRACT:
SUBMITTER: Gao Z
PROVIDER: S-EPMC3365543 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Neurod1 is essential for the survival and maturation of adult-born neurons.
Gao Zhengliang Z Ure Kerstin K Ables Jessica L JL Lagace Diane C DC Nave Klaus-Armin KA Goebbels Sandra S Eisch Amelia J AJ Hsieh Jenny J
Nature neuroscience 20090823 9
The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons. ...[more]
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