Ontology highlight
ABSTRACT:
SUBMITTER: Sura L
PROVIDER: S-EPMC3365772 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Sura Lucie L Zíma Vlastimil V Marsakova Lenka L Hynkova Anna A Barvík Ivan I Vlachova Viktorie V
The Journal of biological chemistry 20120329 22
The transient receptor potential ankyrin 1 (TRPA1) channel is a Ca(2+)-permeable cation channel whose activation results from a complex synergy between distinct activation sites, one of which is especially important for determining its sensitivity to chemical, voltage and cold stimuli. From the cytoplasmic side, TRPA1 is critically regulated by Ca(2+) ions, and this mechanism represents a self-modulating feedback loop that first augments and then inhibits the initial activation. We investigated ...[more]