Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity.
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ABSTRACT:
SUBMITTER: Andersen EC
PROVIDER: S-EPMC3365839 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity.
Andersen Erik C EC Gerke Justin P JP Shapiro Joshua A JA Crissman Jonathan R JR Ghosh Rajarshi R Bloom Joshua S JS Félix Marie-Anne MA Kruglyak Leonid L
Nature genetics 20120129 3
The nematode Caenorhabditis elegans is central to research in molecular, cell and developmental biology, but nearly all of this research has been conducted on a single strain of C. elegans. Little is known about the population genomic and evolutionary history of this species. We characterized C. elegans genetic variation using high-throughput selective sequencing of a worldwide collection of 200 wild strains and identified 41,188 SNPs. Notably, C. elegans genome variation is dominated by a set o ...[more]
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