Ontology highlight
ABSTRACT:
SUBMITTER: Ying T
PROVIDER: S-EPMC3365978 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Ying Tianlei T Chen Weizao W Gong Rui R Feng Yang Y Dimitrov Dimiter S DS
The Journal of biological chemistry 20120419 23
Antibody fragments are emerging as promising biopharmaceuticals because of their relatively small size and other unique properties. However, compared with full-size antibodies, these antibody fragments lack the ability to bind the neonatal Fc receptor (FcRn) and have reduced half-lives. Fc engineered to bind antigens but preserve interactions with FcRn and Fc fused with monomeric proteins currently are being developed as candidate therapeutics with prolonged half-lives; in these and other cases, ...[more]