Ontology highlight
ABSTRACT:
SUBMITTER: Laurie CC
PROVIDER: S-EPMC3366033 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Laurie Cathy C CC Laurie Cecelia A CA Rice Kenneth K Doheny Kimberly F KF Zelnick Leila R LR McHugh Caitlin P CP Ling Hua H Hetrick Kurt N KN Pugh Elizabeth W EW Amos Chris C Wei Qingyi Q Wang Li-e LE Lee Jeffrey E JE Barnes Kathleen C KC Hansel Nadia N NN Mathias Rasika R Daley Denise D Beaty Terri H TH Scott Alan F AF Ruczinski Ingo I Scharpf Rob B RB Bierut Laura J LJ Hartz Sarah M SM Landi Maria Teresa MT Freedman Neal D ND Goldin Lynn R LR Ginsburg David D Li Jun J Desch Karl C KC Strom Sara S SS Blot William J WJ Signorello Lisa B LB Ingles Sue A SA Chanock Stephen J SJ Berndt Sonja I SI Le Marchand Loic L Henderson Brian E BE Monroe Kristine R KR Heit John A JA de Andrade Mariza M Armasu Sebastian M SM Regnier Cynthia C Lowe William L WL Hayes M Geoffrey MG Marazita Mary L ML Feingold Eleanor E Murray Jeffrey C JC Melbye Mads M Feenstra Bjarke B Kang Jae H JH Wiggs Janey L JL Jarvik Gail P GP McDavid Andrew N AN Seshan Venkatraman E VE Mirel Daniel B DB Crenshaw Andrew A Sharopova Nataliya N Wise Anastasia A Shen Jess J Crosslin David R DR Levine David M DM Zheng Xiuwen X Udren Jenna I JI Bennett Siiri S Nelson Sarah C SC Gogarten Stephanie M SM Conomos Matthew P MP Heagerty Patrick P Manolio Teri T Pasquale Louis R LR Haiman Christopher A CA Caporaso Neil N Weir Bruce S BS
Nature genetics 20120506 6
We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies. This detection method requires a relatively high frequency of cells with the same abnormal karyotype (>5-10%; presumably of clonal origin) in the presence of normal cells. The frequency of detectable clonal mosaicism in peripheral blood is low (<0.5%) from birth until 50 years of age, after ...[more]