Ontology highlight
ABSTRACT:
SUBMITTER: Gardner A
PROVIDER: S-EPMC3366074 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Gardner Aaron A Fisher Andrew J AJ Richter Christine C Johnson Gail E GE Moisey Elizabeth J EJ Brodlie Malcolm M Ward Christopher C Krippner-Heidenreich Anja A Mann Derek A DA Borthwick Lee A LA
The American journal of pathology 20120421 6
Therapies to limit or reverse fibrosis have proven unsuccessful, highlighting the need for a greater understanding of basic mechanisms that drive fibrosis and, in particular, the link between fibrosis and inflammation. It has been shown that pro-fibrotic transforming growth factor β1 (TGF-β1)-driven epithelial-to-mesenchymal transition (EMT) can be accentuated by tumor necrosis factor α (TNF-α). TGF-β-activated kinase 1 (TAK1) is activated by both TGF-β1 and TNF-α, activating both nuclear factor ...[more]