Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-?B, PPAR? and PPAR? and the Respective Bioactive Compounds.
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ABSTRACT:
SUBMITTER: Rozema E
PROVIDER: S-EPMC3366346 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds.
Rozema E E Atanasov A G AG Fakhrudin N N Singhuber J J Namduang U U Heiss E H EH Reznicek G G Huck C W CW Bonn G K GK Dirsch V M VM Kopp B B
Evidence-based complementary and alternative medicine : eCAM 20120523
Chinese herbal medicinal (CHM) extracts from fourteen plants were investigated in cell-based in vitro assays for their effect on nuclear factor κB (NF-κB), a key regulator of inflammation, as well as on peroxisome proliferator-activated receptors (PPARs) being key regulators of genes involved in lipid and glucose metabolism. 43% of the investigated CHMs showed NF-κB inhibitory and 50% PPARα and PPARγ activating effects. Apolar extracts from cortex and flos of Albizia julibrissin Durazz. and proc ...[more]
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