Ontology highlight
ABSTRACT:
SUBMITTER: Yao H
PROVIDER: S-EPMC3366403 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Yao Hongwei H Chung Sangwoon S Hwang Jae-woong JW Rajendrasozhan Saravanan S Sundar Isaac K IK Dean David A DA McBurney Michael W MW Guarente Leonard L Gu Wei W Rönty Mikko M Kinnula Vuokko L VL Rahman Irfan I
The Journal of clinical investigation 20120501 6
Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a NAD+-dependent protein/histone deacetylase, is reduced in lungs of patients with COPD. However, the molecular signals underlying the premature aging in lungs, and whether SIRT1 protects against cellular senescence and various pathophysiological alterations in emphysema, remai ...[more]