Ontology highlight
ABSTRACT:
SUBMITTER: Distler MG
PROVIDER: S-EPMC3366407 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Distler Margaret G MG Plant Leigh D LD Sokoloff Greta G Hawk Andrew J AJ Aneas Ivy I Wuenschell Gerald E GE Termini John J Meredith Stephen C SC Nobrega Marcelo A MA Palmer Abraham A AA
The Journal of clinical investigation 20120515 6
Glyoxalase 1 (Glo1) expression has previously been associated with anxiety in mice; however, its role in anxiety is controversial, and the underlying mechanism is unknown. Here, we demonstrate that GLO1 increases anxiety by reducing levels of methylglyoxal (MG), a GABAA receptor agonist. Mice overexpressing Glo1 on a Tg bacterial artificial chromosome displayed increased anxiety-like behavior and reduced brain MG concentrations. Treatment with low doses of MG reduced anxiety-like behavior, while ...[more]