Ontology highlight
ABSTRACT:
SUBMITTER: Keady BT
PROVIDER: S-EPMC3366633 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Developmental cell 20120501 5
The intraflagellar transport (IFT) system is required for building primary cilia, sensory organelles that cells use to respond to their environment. IFT particles are composed of about 20 proteins, and these proteins are highly conserved across ciliated species. IFT25, however, is absent from some ciliated organisms, suggesting that it may have a unique role distinct from ciliogenesis. Here, we generate an Ift25 null mouse and show that IFT25 is not required for ciliary assembly but is required ...[more]