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Studies toward the synthesis of spirolide C: exploration into the formation of the 23-membered all-carbon macrocyclic framework.

ABSTRACT: The synthesis of two complex subunits en route to spirolide C is described. A key alkyllithium addition to an aldehyde joins the fragments, which are advanced in order to investigate a ring-closing metathesis to form the 23-membered all-carbon macrocyclic framework.

SUBMITTER: Stivala CE

PROVIDER: S-EPMC3366693 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Studies toward the synthesis of spirolide C: exploration into the formation of the 23-membered all-carbon macrocyclic framework.

Stivala Craig E CE Gu Zhenhua Z Smith Lindsay L LL Zakarian Armen A

Organic letters 20120119 3

The synthesis of two complex subunits en route to spirolide C is described. A key alkyllithium addition to an aldehyde joins the fragments, which are advanced in order to investigate a ring-closing metathesis to form the 23-membered all-carbon macrocyclic framework. ...[more]

PMID: 22260643

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