Allele-specific p53 mutant reactivation.
Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC3366694 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Allele-specific p53 mutant reactivation.
Yu Xin X Vazquez Alexei A Levine Arnold J AJ Carpizo Darren R DR
Cancer cell 20120501 5
Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the National Cancer Institute's anticancer drug screen data, we identified two compounds from the thiosemicarbazone family that manifest increased growth inhibitory activity in mutant p53 cells, particularly for the p53(R175) mutant. Mechanistic studies reveal that NSC319726 restores WT structure and function to the p53(R175) mutant. This compound kills p53(R172H) knockin mice with extensive apoptosis ...[more]
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