Tumors with nonfunctional retinoblastoma protein are killed by reduced ?-tubulin levels.
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ABSTRACT:
SUBMITTER: Ehlen A
PROVIDER: S-EPMC3366773 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Tumors with nonfunctional retinoblastoma protein are killed by reduced γ-tubulin levels.
Ehlén Åsa Å Rosselló Catalina A CA von Stedingk Kristoffer K Höög Greta G Nilsson Elise E Pettersson Helen M HM Jirström Karin K Alvarado-Kristensson Maria M
The Journal of biological chemistry 20120406 21
In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ-tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ-tubulin protein levels results in an E2F1-dependent up-regulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ-tubulin and RB1 ...[more]
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