Ontology highlight
ABSTRACT:
SUBMITTER: Bruser A
PROVIDER: S-EPMC3366854 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Brüser Antje A Kirchberger Jürgen J Kloos Marco M Sträter Norbert N Schöneberg Torsten T
The Journal of biological chemistry 20120403 21
6-Phosphofructokinases (Pfk) are homo- and heterooligomeric, allosteric enzymes that catalyze one of the rate-limiting steps of the glycolysis: the phosphorylation of fructose 6-phosphate at position 1. Pfk activity is modulated by a number of regulators including adenine nucleotides. Recent crystal structures from eukaryotic Pfk revealed several adenine nucleotide binding sites. Herein, we determined the functional relevance of two adenine nucleotide binding sites through site-directed mutagene ...[more]