Dataset Information

Social differences in lung cancer management and survival in South East England: a cohort study.

ABSTRACT:

Objective

To examine possible social variations in lung cancer survival and assess if any such gradients can be attributed to social differences in comorbidity, stage at diagnosis or treatment.

Design

Population-based cohort identified in the Thames Cancer Registry.

Setting

South East England.

Participants

15?582 lung cancer patients diagnosed between 2006 and 2008.

Main outcome measures

Stage at diagnosis, surgery, radiotherapy, chemotherapy and survival.

Results

The likelihood of being diagnosed as having early-stage disease did not vary by socioeconomic quintiles (p=0.58). In early-stage non-small-cell lung cancer, the likelihood of undergoing surgery was lowest in the most deprived group. There were no socioeconomic differences in the likelihood of receiving radiotherapy in stage III disease, while in advanced disease and in small-cell lung cancer, receipt of chemotherapy differed over socioeconomic quintiles (p<0.01). In early-stage disease and following adjustment for confounders, the HR between the most deprived and the most affluent group was 1.24 (95% CI 0.98 to 1.56). Corresponding estimates in stage III and advanced disease or small-cell lung cancer were 1.16 (95% CI 1.01 to 1.34) and 1.12 (95% CI 1.05 to 1.20), respectively. In early-stage disease, the crude HR between the most deprived and the most affluent group was approximately 1.4 and constant through follow-up, while in patients with advanced disease or small-cell lung cancer, no difference was detectable after 3 months.

Conclusion

We observed socioeconomic variations in management and survival in patients diagnosed as having lung cancer in South East England between 2006 and 2008, differences which could not fully be explained by social differences in stage at diagnosis, co-morbidity and treatment. The survival observed in the most affluent group should set the target for what is achievable for all lung cancer patients, managed in the same healthcare system.

SUBMITTER: Berglund A

PROVIDER: S-EPMC3367157 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Social differences in lung cancer management and survival in South East England: a cohort study.

Berglund Anders A Lambe Mats M Lüchtenborg Margreet M Linklater Karen K Peake Michael D MD Holmberg Lars L Møller Henrik H

BMJ open 20120525 3

<h4>Objective</h4>To examine possible social variations in lung cancer survival and assess if any such gradients can be attributed to social differences in comorbidity, stage at diagnosis or treatment.<h4>Design</h4>Population-based cohort identified in the Thames Cancer Registry.<h4>Setting</h4>South East England.<h4>Participants</h4>15 582 lung cancer patients diagnosed between 2006 and 2008.<h4>Main outcome measures</h4>Stage at diagnosis, surgery, radiotherapy, chemotherapy and survival.<h4> ...[more]

PMID: 22637374

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Dataset Information

Social differences in lung cancer management and survival in South East England: a cohort study.

Objective

Design

Setting

Participants

Main outcome measures

Results

Conclusion

Publications

Social differences in lung cancer management and survival in South East England: a cohort study.

Similar Datasets

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