Ontology highlight
ABSTRACT:
SUBMITTER: Geissler R
PROVIDER: S-EPMC3367175 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Geissler Rene R Golbik Ralph P RP Behrens Sven-Erik SE
Nucleic acids research 20120209 11
The DEAD-box helicase DDX3 has suggested functions in innate immunity, mRNA translocation and translation, and it participates in the propagation of assorted viruses. Exploring initially the role of DDX3 in the life cycle of hepatitis C virus, we observed the protein to be involved in translation directed by different viral internal ribosomal entry sites. Extension of these studies revealed a general supportive role of DDX3 in translation initiation. DDX3 was found to interact in an RNA-independ ...[more]