Ontology highlight
ABSTRACT:
SUBMITTER: Coluzza I
PROVIDER: S-EPMC3367531 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Coluzza Ivan I MacDonald James T JT Sadowski Michael I MI Taylor William R WR Goldstein Richard A RA
PloS one 20120523 5
A general understanding of the complex phenomenon of protein evolution requires the accurate description of the constraints that define the sub-space of proteins with mutations that do not appreciably reduce the fitness of the organism. Such constraints can have multiple origins, in this work we present a model for constrained evolutionary trajectories represented by a markovian process throughout a set of protein-like structures artificially constructed to be topological intermediates between t ...[more]