Ontology highlight
ABSTRACT:
SUBMITTER: Giridharan SS
PROVIDER: S-EPMC3367829 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Giridharan Sai Srinivas Panapakkam SS Rohn Jennifer L JL Naslavsky Naava N Caplan Steve S
Journal of cell science 20120213 Pt 3
The Drosophila melanogaster MICAL protein is essential for the neuronal growth cone machinery that functions through plexin- and semaphorin-mediated axonal signaling. Drosophila MICAL is also involved in regulating myofilament organization and synaptic structures, and serves as an actin disassembly factor downstream of plexin-mediated axonal repulsion. In mammalian cells there are three known isoforms, MICAL1, MICAL2 and MICAL3, as well as the MICAL-like proteins MICAL-L1 and MICAL-L2, but littl ...[more]