Prediction of cytogenetic abnormalities with gene expression profiles.
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ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC3367903 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Prediction of cytogenetic abnormalities with gene expression profiles.
Zhou Yiming Y Zhang Qing Q Stephens Owen O Heuck Christoph J CJ Tian Erming E Sawyer Jeffrey R JR Cartron-Mizeracki Marie-Astrid MA Qu Pingping P Keller Jason J Epstein Joshua J Barlogie Bart B Shaughnessy John D JD
Blood 20120410 21
Cytogenetic abnormalities are important clinical parameters in various types of cancer, including multiple myeloma. We developed a model to predict cytogenetic abnormalities in patients with multiple myeloma using gene expression profiling and validated it by different cytogenetic techniques. The model has an accuracy rate up to 0.89. These results provide proof of concept for the hypothesis that gene expression profiling is a superior genomic method for clinical molecular diagnosis and/or progn ...[more]
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