Ontology highlight
ABSTRACT:
SUBMITTER: Faroudi M
PROVIDER: S-EPMC3368586 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Faroudi Mustapha M Hons Miroslav M Zachacz Agnieszka A Dumont Celine C Lyck Ruth R Stein Jens V JV Tybulewicz Victor L J VL
Blood 20100924 25
Naive T cells continuously recirculate between secondary lymphoid tissue via the blood and lymphatic systems, a process that maximizes the chances of an encounter between a T cell and its cognate antigen. This recirculation depends on signals from chemokine receptors, integrins, and the sphingosine-1-phosphate receptor. The authors of previous studies in other cell types have shown that Rac GTPases transduce signals leading to cell migration and adhesion; however, their roles in T cells are unkn ...[more]