Ontology highlight
ABSTRACT:
SUBMITTER: Lawson VA
PROVIDER: S-EPMC3368636 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
ACS chemical neuroscience 20100930 11
Apoptotic cell death via activation of the caspase family of cysteine proteases is a common feature of many neurodegenerative diseases including Creutzfeldt-Jakob disease. Molecular imaging of cysteine protease activities at the preclinical stage may provide valuable mechanistic information about pathophysiological pathways involved in disease evolution and in response to therapy. In this study, we report synthesis and characterization of a near-infrared (NIR) fluorescent contrast agent capable ...[more]