Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.
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ABSTRACT:
SUBMITTER: Van Aller GS
PROVIDER: S-EPMC3368817 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.
Van Aller Glenn S GS Reynoird Nicolas N Barbash Olena O Huddleston Michael M Liu Shichong S Zmoos Anne-Flore AF McDevitt Patrick P Sinnamon Robert R Le BaoChau B Mas Gloria G Annan Roland R Sage Julien J Garcia Benjamin A BA Tummino Peter J PJ Gozani Or O Kruger Ryan G RG
Epigenetics 20120401 4
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides a potential new link between chromatin dynamics and neoplastic disease. ...[more]
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