Ontology highlight
ABSTRACT:
SUBMITTER: Lillie PJ
PROVIDER: S-EPMC3369564 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Lillie Patrick J PJ Berthoud Tamara K TK Powell Timothy J TJ Lambe Teresa T Mullarkey Caitlin C Spencer Alexandra J AJ Hamill Matthew M Peng Yanchun Y Blais Marie-Eve ME Duncan Christopher J A CJ Sheehy Susanne H SH Havelock Tom T Faust Saul N SN Williams Rob Lambkin RL Gilbert Anthony A Oxford John J Dong Tao T Hill Adrian V S AV Gilbert Sarah C SC
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120322 1
<h4>Background</h4>The novel influenza vaccine MVA-NP+M1 is designed to boost cross-reactive T-cell responses to internal antigens of the influenza A virus that are conserved across all subtypes, providing protection against both influenza disease and virus shedding against all influenza A viruses. Following a phase 1 clinical study that demonstrated vaccine safety and immunogenicity, a phase 2a vaccination and influenza challenge study has been conducted in healthy adult volunteers.<h4>Methods< ...[more]