Ontology highlight
ABSTRACT:
SUBMITTER: Fan Q
PROVIDER: S-EPMC3369958 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Fan Qiao Q Barathi Veluchamy A VA Cheng Ching-Yu CY Zhou Xin X Meguro Akira A Nakata Isao I Khor Chiea-Chuen CC Goh Liang-Kee LK Li Yi-Ju YJ Lim Wan'e W Ho Candice E H CE Hawthorne Felicia F Zheng Yingfeng Y Chua Daniel D Inoko Hidetoshi H Yamashiro Kenji K Ohno-Matsui Kyoko K Matsuo Keitaro K Matsuda Fumihiko F Vithana Eranga E Seielstad Mark M Mizuki Nobuhisa N Beuerman Roger W RW Tai E-Shyong ES Yoshimura Nagahisa N Aung Tin T Young Terri L TL Wong Tien-Yin TY Teo Yik-Ying YY Saw Seang-Mei SM
PLoS genetics 20120607 6
As one of the leading causes of visual impairment and blindness, myopia poses a significant public health burden in Asia. The primary determinant of myopia is an elongated ocular axial length (AL). Here we report a meta-analysis of three genome-wide association studies on AL conducted in 1,860 Chinese adults, 929 Chinese children, and 2,155 Malay adults. We identified a genetic locus on chromosome 1q41 harboring the zinc-finger 11B pseudogene ZC3H11B showing genome-wide significant association w ...[more]