Ontology highlight
ABSTRACT:
SUBMITTER: Bradfield JP
PROVIDER: S-EPMC3370100 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Bradfield Jonathan P JP Taal H Rob HR Timpson Nicholas J NJ Scherag André A Lecoeur Cecile C Warrington Nicole M NM Hypponen Elina E Holst Claus C Valcarcel Beatriz B Thiering Elisabeth E Salem Rany M RM Schumacher Fredrick R FR Cousminer Diana L DL Sleiman Patrick M A PM Zhao Jianhua J Berkowitz Robert I RI Vimaleswaran Karani S KS Jarick Ivonne I Pennell Craig E CE Evans David M DM St Pourcain Beate B Berry Diane J DJ Mook-Kanamori Dennis O DO Hofman Albert A Rivadeneira Fernando F Uitterlinden André G AG van Duijn Cornelia M CM van der Valk Ralf J P RJ de Jongste Johan C JC Postma Dirkje S DS Boomsma Dorret I DI Gauderman W James WJ Hassanein Mohamed T MT Lindgren Cecilia M CM Mägi Reedik R Boreham Colin A G CA Neville Charlotte E CE Moreno Luis A LA Elliott Paul P Pouta Anneli A Hartikainen Anna-Liisa AL Li Mingyao M Raitakari Olli O Lehtimäki Terho T Eriksson Johan G JG Palotie Aarno A Dallongeville Jean J Das Shikta S Deloukas Panos P McMahon George G Ring Susan M SM Kemp John P JP Buxton Jessica L JL Blakemore Alexandra I F AI Bustamante Mariona M Guxens Mònica M Hirschhorn Joel N JN Gillman Matthew W MW Kreiner-Møller Eskil E Bisgaard Hans H Gilliland Frank D FD Heinrich Joachim J Wheeler Eleanor E Barroso Inês I O'Rahilly Stephen S Meirhaeghe Aline A Sørensen Thorkild I A TI Power Chris C Palmer Lyle J LJ Hinney Anke A Widen Elisabeth E Farooqi I Sadaf IS McCarthy Mark I MI Froguel Philippe P Meyre David D Hebebrand Johannes J Jarvelin Marjo-Riitta MR Jaddoe Vincent W V VW Smith George Davey GD Hakonarson Hakon H Grant Struan F A SF
Nature genetics 20120501 5
Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yie ...[more]