Ontology highlight
ABSTRACT:
SUBMITTER: Adachi R
PROVIDER: S-EPMC3370188 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Adachi Roberto R Krilis Steven A SA Nigrovic Peter A PA Hamilton Matthew J MJ Chung Kyungemee K Thakurdas Shakeel M SM Boyce Joshua A JA Anderson Paul P Stevens Richard L RL
The Journal of biological chemistry 20120416 24
RasGRP4 (Ras guanine nucleotide-releasing protein-4) is an intracellular, calcium-regulated guanine nucleotide exchange factor and diacylglycerol/phorbol ester receptor expressed in mast cells (MCs) and their progenitors. To study the function of this signaling protein in inflammatory disorders, a homologous recombination approach was used to create a RasGRP4-null C57BL/6 mouse line. The resulting transgenic animals had normal numbers of MCs in their tissues that histochemically and morphologica ...[more]