Ontology highlight
ABSTRACT:
SUBMITTER: Beitz E
PROVIDER: S-EPMC337022 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Beitz Eric E Pavlovic-Djuranovic Slavica S Yasui Masato M Agre Peter P Schultz Joachim E JE
Proceedings of the National Academy of Sciences of the United States of America 20040120 5
The selectivity of aquaporins for water and solutes is determined by pore diameter. Paradoxically, the wider pores of glycerol facilitators restrict water passage by an unknown mechanism. Earlier we characterized an aquaglyceroporin from Plasmodium falciparum with high permeability for both glycerol and water. We use point mutations to demonstrate that amino acids directly lining the pore are not responsible for the excellent water permeability of the Plasmodium aquaglyceroporin but affect perme ...[more]