Ontology highlight
ABSTRACT:
SUBMITTER: Granville DJ
PROVIDER: S-EPMC337051 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Granville David J DJ Tashakkor Babak B Takeuchi Cindy C Gustafsson Asa B AB Huang Chengqun C Sayen M Richard MR Wentworth Paul P Yeager Mark M Gottlieb Roberta A RA
Proceedings of the National Academy of Sciences of the United States of America 20040120 5
Ischemia and reperfusion both contribute to tissue damage after myocardial infarction. Although many drugs have been shown to reduce infarct size when administered before ischemia, few have been shown to be effective when administered at reperfusion. Moreover, although it is generally accepted that a burst of reactive oxygen species (ROS) occurs at the onset of reperfusion and contributes to tissue damage, the source of ROS and the mechanism of injury is unclear. We now report the finding that c ...[more]